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From a technical viewpoint, Lister was not an exceptional surgeon, [2] but his research into bacteriology and infection in wounds raised his operative technique to a new plane where his observations, deductions and practices revolutionised surgery throughout the world. Lister's contributions were four-fold. Firstly, as a surgeon at the Glasgow Royal Infirmary , he introduced carbolic acid modern-day phenol as a steriliser for surgical instruments, patients' skins, sutures , surgeons' hands, and wards, promoting the principle of antiseptics.
Secondly, he researched the role of inflammation and tissue perfusion in the healing of wounds. Thirdly, he advanced diagnostic science by analyzing specimens using microscopes. Fourthly, he devised strategies to increase the chances of survival after surgery. His most important contribution, however, was recognising that putrefaction in wounds is caused by germs, in connection to Louis Pasteur 's then-novel germ theory of fermentation.
Lister's work led to a reduction in post-operative infections and made surgery safer for patients, leading to him being distinguished as the "father of modern surgery". Lister was born to a prosperous, educated Quaker family in the village of Upton , then near but now in London , [8] England.
Lister's paternal great-great-grandfather, Thomas Lister, was the last of several generations of farmers who lived in Bingley in West Yorkshire. Lister's grandfather was apprenticed to a watchmaker, Isaac Rogers, [15] in and followed that trade on his own account in Bell Alley, Lombard Street from to He then took over his father's tobacco business, [13] but gave it up in in favour of working at his father-in-law Stephen Jackson's business as a wine-merchant at No 28 Old Wine and Brandy Values on Lothbury Street, opposite Tokenhouse Yard.
His father was a pioneer in the design of achromatic object lenses for use in compound microscopes [8] He spent 30 years perfecting the microscope, and in the process, discovered the Law of Aplanatic Foci , [17] building a microscope where the image point of one lens coincided with the focal point of another. The eldest daughter of the couple was Mary Lister. He became Lister's biographer in Lister's other brother was William Henry Lister, who died after a long illness.