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Just for Khao San Road one week is too much but nobody prevents you from visiting the rest of Bangkok and the neighbouring provinces like Samut Prakan for Ancient City. No need to be paranoid. However, there will be some locals and foreigners who will try to scam you. No difference to other tourist areas in Bangkok. Not bigger or less than anywhere else. How far would you trust someone who has interacted with you for a few hours in your own country? It depends on which kind of nightlife you want.
The neighbourhood has discos, music bars, pool bars, and plain restaurants. I have not seen agogo bars or karaoke. The most important thing is not getting too drunk although the bars are selling cheap buckets of spirits and mixer. Sometimes there are big crowds, so pickpockets can be a risk, although I'm not aware of any incidents.
Not traveling solo would not help with that, anyway. Way too long! You'll be bored after 3 or 4 days shopping. Nothing else in Bangkok but temples and how many of them can you do?? Yes if you don't drink too much you'll be fine.. And just hop in a taxi and leave an area of you don't feel safe but generally it's very safe and even in the early hours of the morning never creepy People are the friendliest on the planet and always help you.
Go to Phuket and do something different while your in Thailand.. You can easily meet other people. Even though the Khao San Road area Banglamphu has no agogo bsrs, the bars have a contingent of prostitutes. Some people willing to talk with you may be expecting to be paid money.
They thought he was Japanese; if they had known he was Thai his money probably would not have been good enough. No condom, either. If you mean go-go bars and beer bars Nana area will have more to walk to. Is one week the total time in Thailand? Do Google check for nightlife Bangkok and Pattaya. While I'm not a mad party raving person I do like a drink and a good time so if you want to meet a fellow solo traveller for a drink then send me a message.